Lab – Hussaini Lab

PhD Neurobiology

(Freie Universitaet Berlin)

I am the head of Laboratory for Systems Neuroscience of Cognition and Dementia at the Center for Dementia Research at NKI. My postdoctoral training was at Columbia University under Dr. Eric Kandel studying the role of h-channels on hippocampal place cell firing and spatial memory in HCN1 knockout mice. Having worked on the entorhinal cortex grid cells in the Moser lab (NTNU), I became interested in how entorhinal cortex neurons are affected in Alzheimer’s disease (AD). My lab aims to understand the mechanism underlying neuronal dysfunction in neurodegenerative diseases such as AD.

PhD Neuroscience

(University of British Columbia)

I am investigating how the neurons of MEC and LEC are affected in Alzheimer’s disease. I’ll use cutting-edge dense electrodes to record from hundreds of neurons to understand the electrophysiological patterns of selective vulnerability. In addition, I will use optogenetic technique to restore neuronal function.

BS Env. Science. (SUNY College)

I work closely with Alyssa to investigate brain regions involved in Alzheimer’s disease. I help with immunohistochemistry, electrophysiology and behavior experiments.

BS Neurobiology (UC Irvine)

MS Mol. Sci. & Software Engg. (UC Berkeley)

I develop computational tools for analyzing datasets from electrophysiology and behavioral experiments. I strive to apply machine learning methods to uncover meaningful insights from complex neural data and to design scalable pipelines for neuroscience research.

BS Neuroscience (Brown University)

I focus on computational tools to analyze large scale datasets from electrophysiology and behavioral experiments in AD mouse models. I incorporate modeling and machine learning approaches to better understand and decode neural data. I also work on data pipelines and software to support general lab analysis tools. I am currently pursuing PhD at NYU.

Alumni

PhD Neuroscience

(Georgetown University)

Currently a Research consultant at Sendero Biosciences. I focused on understanding how neuronal populations in the entorhinal cortex (EC) and hippocampus (HIPP) are affected by amyloid-beta (Aβ) and tau pathology, which are hallmark features of Alzheimer’s disease. I employed chemogenetics and in vivo electrophysiology in my research, and am interested in how neuronal modulation can effect Aβ accumulation and pathological tau in the entorhinal cortex – hippocampal (EC-HIPP) network.

PhD Neuroscience

(National University of Singapore)

Currently a postdoc at University of Glasgow. I studied early signs of neuronal vulnerability in locus coeruleus using in vivo recordings in the neurons of the hippocampus (HPC). I used human tau lysates in mice to address if tau pathology in locus coeruleus impacts downstream hippocampal neurons.

BS Neuroscience (Fordham University)

I worked closely with Dr. Radha Raghuraman and work on optimizing immunohistochemistry protocols and their visualizations. Currently at Montclair University.

MS Biomedical Engineering

(Columbia University)

Currently at PathOmiq. I developed and maintained software for data analysis obtained from single-unit electrophysiology experiments.

MA Statistics and Applied Mathematics

(City University of New York, Hunter College)

Currently at NextGen Healthcare. I developed techniques for making sense of neural data using statistics and machine learning. I worked on Earth Mover’s Distance and NeuronTracker algorithm.

BA Biology (Skidmore College)

Currently at Regeneron. I worked closely with Dr. Rodriguez, doing in-vivo electrophysiology recordings in mouse models of AD, and performed tissue sectioning, IHC and IF staining.

PhD Neuroscience

Istanbul University

Currently in DRI, UCL. I worked on the role of NMDA receptors in aging and disease as part of my PhD thesis funded by Fulbright Scholarship. Currently at Istanbul University.

MA Cell, Molecular, and Biomedical Studies

(Columbia University)

Currently a postdoc at University of Washington. I graduated in 2022. I studied the role of, and possible treatments for, miRNA dysregulation in tau pathology.

PhD Neuroscience

(University College London)

Currently a freelance behavioral scientist. I assisted with analysis of electrophysiology data from the lateral entorhinal cortex in AD, contribute to manuscript writing and academically mentor students who are interning in the lab. Worked at IQVIA in London.

BS Biology

Currently at Columbia University. I performed animal husbandry of several transgenic lines and helped with behavioral experiments. Currently at Columbia University.

BS Biomedical Engineering

(Boston University)

Currently pursuing MS at Columbia University. I helped with code for spatial analysis tool, spatial spectral mapper and other tools. Github. Currently a graduate student at Columbia Engineering. Worked at PathAI.

BS Computer Science

(Drexel University)

Currently at Replica Analytics. I helped with code development of hfoGUI, GebaSpike and other tools. GitHub

Medical Doctor

(Stockholm, Sweden)

Currently a Medical Doctor in Stockholm. I worked on the research and design of BrainWiki- a comparative neuroanatomy tool (BrainWiki.org).

David Vaughan – NeuroScikit 2.0 backend consultant (2023), Dilip Rajeswari – ML & DS consultant (2021-2022), Alice Zambon- Visiting graduate student (2019), Aisha Kazeem- Research assistant (2018-2019), Valerie Savage- Research technician (2016-2017), Eden Nahmani- Research technician (2015-2016), Eliana Goldberg- Bachelor’s student (2015-2016).

Interns– Arnav Panigrahi, Lauren Davidson, Katie Lim, Grace Wang, Sierra Deadhari, Nikhil Ramavenkat, Elakiya Jayaraman, Yash Tiwari, Matthew Spence, Alaa Ali, Ella Wilson, Julia Wu-Oswald, Nava Himelhoch, Soham Bafana, Ray Muroi, Sandhya Senthilkumar, Deeksha Kommireddi, Jessica George, Matthew Hou, Jessica Hui, Kaelin Main, Xavier Cambi, Talya Waxenburg, Matthew Hou, Adithi Jayaraman, Lisa Shah, Shaunice Grier, Michael Kim, Keerthi Jayaraman, Surya Krishnamurthy, Sarah Rogers, Hannah Straus, Ken Gjoni, Alejandro Capote, Masayuki Yanagiba, Yagiz Meric Altun, Arjun Gupta, Mark McNulty, Peter Salamon and Kyle Peter.

Hussaini Lab

Abid Hussaini

Alyssa Ash

Cristina Vargas

Julian Dolan

Andrew Aoun

Alumni

Gustavo Rodriguez

Radha Raghuraman

Thomas Tedesco

Anurag Sharma

Oliver Shetler

Eva Rothenberg

Hande Yuceer Korkmaz

Joshua Cho

Alexandra Petrache

Helen Figueroa

Srujan Vajram

Geoffrey Barrett

Linda Forsell